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Analytical challenges and recent advances in the determination of estrogens in water environments

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Rodica Domnica Briciu, Agata Kot-Wasik, Jacek Namiesnik

Editorial: Journal of Chromatographic Science, 47, p.127-139, 2009.


Estrogens have been shown to be present in the water compartment,
mainly due to the inefficient removal in wastewater treatment plants
(WWTP). The concentrations of these compounds, although very low
(low ng/L), are sufficient to induce estrogenic responses and alter the
normal reproduction and development of wildlife organisms. The
compounds have been determined, by a variety of analytical
procedures, in the influents and effluents of WWTP, fresh waters, rivers,
and even drinking waters. Determination of natural and synthetic
estrogens and progestogens in natural water is, however, a difficult
analytical task, because of the very low detection limits required and
the complexity of the matrix. Thus, in general, complicated, timeconsuming
extraction and purification processes, usually based on the
application of solid–liquid extraction, are performed before final
determination by immunoassay, high-performance liquid
chromatography, or gas chromatography, very often coupled with mass
spectrometry. This paper reviews the analytical methods so far
described for the analysis of estrogens, which are currently important
environmental pollutants presented in natural and wastewaters.
Discuss of the main steps, from sampling up to analysis, and the
techniques most commonly used in the determination is presented.

Cuvinte cheie: Estrogeni, HPLC // Estrogens, HPLC