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Apoptosis, paraptosis, necrosis, and cell regeneration in posttraumatic cerebral arteries

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Leon Danaila, Irinel Popescu, Viorel Pais, Dan Riga, Sorin Riga, Emil Pais

Editorial: Romanian Society of Surgery, Chirurgia (Bucur), 108(3), p.319-324, 2013.


This study is to understand the nature and functional significance of the activated cell death programs and rehabilitation signs during late vascular changes after brain injury. We used light and transmission electron microscopy to describe changes of cells within the vascular endothelium and tunica media of the cortical arteries four weeks after craniocerebral traumatism. Within tunica media of the posttraumatic damaged artery, apoptotic and paraptotic phenotypes were identified as well as some early ultrastructural signs of smooth muscle cells regeneration, these cell highlighting a remarkable degree of plasticity. Surprisingly, some endothelial cells showed an extensive rough endoplasmic reticulum development, whereas other endothelial cells showed typical necrosis. In conclusion, two groups of suicidal cells- apoptotic and paraptotic cells – were encountered in the same lesional vascular wall after neurotrauma, showing also signs of cell regeneration. The pathophysiologic significance of the coexisting double cell death programs and cell regeneration seems to be in relation with late cell survival, after arterial damage when some cells disappear and other cells try to survive undergoing reversible injury.

Cuvinte cheie: artere cerebrale posttraumatice, apoptoza, paraptoza, necroza, regenerare celulara, ultrastructura // posttraumatic cerebral arteries, apoptosis, paraptosis, necrosis, cell regeneration, ultrastructure