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Double Amino Functionalized Ag Nanoparticles as SERS Tags in Raman Diagnostic

Domenii publicaţii > Fizica + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Simona Cîntã Pînzaru,* Alexandra Falamaş, Cristina Dehelean, Cristian Morari, and Monica Venter

Editorial: Croatica Chemica Acta, 86(3), p.233-244, 2013.


Surface enhanced Raman scattering (SERS) effect is currently exploited as the basis of a new
type of optical labels for in vivo investigation of the tissues, especially for early medical diagnostic. Silver
colloidal nanoparticles decorated with chemisorbed cresyl violet molecular species could act as hybrid
SERS labels. Their Raman scattering properties have been characterized here using different SERS techniques,
and probing different excitation wavelengths, even in the near infrared. Obtaining FT-SERS signal
of cresyl violet is of particular importance for applying FT-Raman spectroscopy to the tissues or cells, in
providing sensitive information in the close vicinity of the SERS label incubated into the biological sample.
Furthermore, upon chemisorption on the silver nanoparticles, cresyl violet molecular orientation provided
both amino functional groups free of interaction with the silver, resulting double aminofunctionalized
Ag nanoparticles suitable for DNA tagging. SERS tests of melanoma induced in mouse using
CV-Ag SERS label suggested the possibility to setup the tissue labeling procedure for skin cancer

Cuvinte cheie: FT-SERS, SERS label, cresyl violet, amino functionalized- Ag nanoparticles