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Changes in NT-proBNP in young children with congenital heart malformations

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Butnariu A, Iancu M, Samasca G, Chira M, Lupan I

Editorial: Laboratory Medicine, 45(1), p.43-47, 2014.


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Objective: We measured serum NT-proBNP levels in 2 groups of young patients (0-36 months) with congestive heart failure (CHF) secondary to congenital heart malformations (CHM). Methods: The first group included 23 patients prior to surgery for heart malformations. The second group included 12 patients with CHM within 24 hours post-operation. NT-proBNP levels were measured by an enzyme-linked immunosorbent immunoassay (ELISA) using the Chem Well 2910 (Awareness Technology Inc.) automated analyzer. Results: NT-proBNP values were 4 times higher in patients with unoperated CHM compared to healthy controls (P <0.001), and 12 times higher in patients with CHM 24 hours after surgery compared to controls (P =0.0001). Conclusions: These results demonstrated significant changes in NT-proBNP concentrations before and after surgery to correct congenital heart malformations.

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Cuvinte cheie: NT-proBNP, ELISA, child aged 0–3 years, heart failure, congenital heart malformation