DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES, ISSN: 1842-3582, Volume: 8, Issue: 3, Pages: 945-953, Published: JUL-SEP 2013,

Abstract: This research aims to use extracts of tropane alkaloids in Datura stramonium using known extraction procedures followed by microencapsulation in order to facilitate environmental protection and sustainable development. The advantage lies in the fact that the release of extracts of plants can be controlled and extended by the chemical mediation. The microcapsules were prepared by the process of the interfacial cross-linking. Tropane alkaloids inhibit the proteinases and native/active site shall be secured, by introducing the microcapsules incorporated in the aqueous phase. The paper studied the effects of the influence of pH of the aqueous phase, PMMA, terephthaloyl chloride concentrations, and the rate of stirring on the morphology and size of the microcapsules. The pH was a determining factor in the amount of microcapsules, influencing the encapsulating yield. The size of the microcapsules varied depending on the speed of mixing 50, 100 and 150 rpm respectively. Infrared spectroscopy was performed on the microcapsules prepared under different conditions. Between the spectral changes, the morphology and size of microcapsules may be set a correlation. It was found that the active substances (tropane alkaloids) protected by encapsulation kept constant their activity after microencapsulation.