Articolele autorului Gabriel Balmus
Link la profilul stiintific al lui Gabriel Balmus

A Unique Role for ITK in Survival of Invariant NKT Cells Associated with the p53-Dependent Pathway in Mice

Invariant NKT (iNKT) cells play important roles in the immune response. ITK and TXK/RLK are Tec family kinases that are expressed in iNKT cells; the expression level of ITK is ∼7-fold higher than that of TXK. Itk−/− mice have reduced iNKT cell frequency and numbers, with defects in development and cytokine secretion that are exacerbated in Itk/Txk double-knockout mice. In contrast, there is no iNKT cell defect in Txk−/− mice. To determine

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Mammalian BTBD12 (SLX4) localizes to meiotic chromosome cores and is essential for normal spermatogenesis

Mutations in genes essential for genome maintenance during meiosis can result in severe disruptions to spermatogenesis and subsequent low fertility and/or birth defects in mammals. The mammalian homolog of yeast plays a critical role in somatic cell repair in mice. Here, we show that this critical function extends to mammalian germ cells, by examining the effects of a Btbd12 gene disruption in mice. Btbd12 mutant mice show severely reduced fertility,

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Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
Cross-species chromosome painting among camel, cattle, pig and human:further insights into the putative Cetartiodactyla ancestral karyotype

The great karyotypic differences between camel, cattle and pig, three important domestic animals, have been a challenge for comparative cytogenetic studies based on conventional cytogenetic approaches. To construct a genome-wide comparative chromosome map among these artiodactyls, we made a set of chromosome painting probes from the dromedary camel (Camelus dromedarius by flow sorting and degenerate oligonucleotide primed-PCR. The painting probes

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Cytogenetic characterization of metaphase chromosomesof alpaca (Lama pacos): I-GTG/RBG-banded karyotypes and ideograms
Chromosome localization of microsatellite markers in the shrews of the Sorex araneus group.
Cytogenetic characterization of alpaca (Lama pacos, fam. Camelidae) prometaphase chromosomes