Canine X-linked muscular dystrophy (c-xmd) is the homologue of human Duchenne muscular dystrophy (DMD), a degenerative disorder that affects 1 in 3,500 boys born worldwide. The disease is caused by mutations in the gene encoding dystrophin, an essential component of the striated muscle cytoskeletal protein complex, leading to progressive skeletal and cardiac muscle damage and early death. Studies in mice have suggested that hematopoietic stem cells

Canine lymphoma is incurable by chemotherapy alone. However, cures are possible with allogeneic hematopoietic cell transplantation if a suitable DLA matched donor can be identified. Here, a 7-year-old male Golden Retriever with spontaneous T-cell lymphoma was induced into clinical remission by two chemotherapy cycles. Twenty-eight members of the dog's pedigree from 5 generations and located in 3 countries were identified. Their blood samples and

The preclinical canine model has proved valuable for the development of principles and techniques of haematopoietic cell transplantation (HCT) applicable to human patients. Studies in random-bred dogs concerning the impact of histocompatibility barriers on engraftment and graft-versus-host disease, the kinetics of immunological reconstitution, the efficacy of various pretransplant conditioning regimens, post-transplantation immunosuppression protocols,

An improved understanding of the pharmacokinetics of mycophenolic acid (MPA), the active metabolite of the immunosuppressant mycophenolate mofetil (MMF), is needed because of the increasing use of MMF in patients undergoing either solid organ or hematopoietic cell transplantation (HCT). Our study sought to determine bioavailability and interdose variability of oral (PO) MMF and the effects of prior and concomitant PO nonabsorbable antibiotics (i.e.,

The thesis “Clinical and Experimental Studies of Hematopoietic Cell Transplantation in Dogs” starts with an overview of the accomplishments over a 50-year period in the field of hematopoietic cell transplantation using the pre-clinical canine model. The hematopoietic cell transplantation methodology currently used in the pre-clinical canine setting is described for the purpose of translation to the veterinary clinical oncology field for the treatment