Poly(methyl methacrylate -pMMA) is used as dental or bone cement. A major drawback of the polymeric biomaterials is that they are radiolucent since they hardly absorb X-ray radiation due to the absence of heavy elements within their structure. The well-known solution is the incorporation of inorganic additives such as baryum sulphate or zirconium dioxide particles. It has been reported that these particles diminish the mechanical properties (especially

This paperwork deals with the obtaining and characterisation of new acrylic cements for bone surgery. The final mixture of cement contains derivatives of methacryloyloxyethyl phosphate, methacrylic acid and 2-acrylamido-2-methyl-1-propane sulphonic acid. The idea of using these monomers is sustained by their ability to form ionic bonds with barium, which is responsible for X-ray reflection and biocompatibility of the polymers derived from these structures.

Methacryloyloxyethyl phosphate is a methacrylic monomer used to modify different substrates by copolymerisation, in order to enhance hydroxyapatite deposition onto their surfaces.We report the synthesis of two copolymers series using increasing concentrations of methacryloyloxyethyl phosphate with (diethylamino) ethyl methacrylate and 1-vinyl-2-pyrrolidinone. Reactivity ratios were evaluated for the two copolymer systems.The influence of phosphate

The polymeric containers (micro or nano) reached a great influence after the development of new information referring to a new concept in the solid tumour biology: EPR effect - enhanced permeability and retention. Taking into account this concept, based on clinical and biochemical results, the solid tumours (including cancer) grow faster than the adjacent tissues, because of a better vascularization and an enhanced permeability, and, as a result,

Cements for orthopaedic or dental surgery are made radio-opaque by using Barium salts or Zirconium oxide particles. We have developed new radio-opaque acrylic cement without such inorganic materials. These cements were obtained by the partial replacement of poly(methyl methacrylate) from the standard cement composition with methacryloyl-oxyethylene phosphate as barium salt, or by the replacement with a copolymer made of methacryloyl-oxyethylene phosphate-barium

Polymers can be interesting alternatives to bone grafts; they must present suitable mechanical and osteoconductive properties. Biomimetic properties may be a key factor for the recognition by bone cells. Methacryloyloxyethyl phosphate (MOEP) was found to enhance hydroxyapatite deposition. The copolymer containing MOEP and 1-vinyl-2-pyrrolidinone (50-50%) binds large amounts of calcium. Particles of the copolymer were used to fill large cranial bone