Resistance to the hormones insulin and leptin are hallmarks in common for type 2 diabetes mellitus and obesity. Both conditions are associated with increased activity and expression of protein tyrosine phosphatase (PTP)1B. Therefore, inhibition of PTP1B activity or down-regulation of its expression should ameliorate insulin and leptin resistance, and may hold therapeutic utility in type 2 diabetes mellitus and obesity control. This background has

The arterial endothelial dysfunction in aging and diabetes remains a clinical problem. We questioned the effect of the low-molecular-weight heparin, enoxaparin, on arterioles contractility in aging and in aging associated with diabetes, and investigated the involvement of the mitogen-activated protein (MAP) kinases pathway in the enoxaparin-mediated effect. The experiments were performed on the isolated resistance arteries of young (4 months old),

The arterial endothelial dysfunction in aging and diabetes remains a clinical problem. We questioned on the effect of the low-molecular-weight heparin, enoxaparin, on arterioles contractility in aging and in aging associated with diabetes, and investigated the involvement of mitogen-activated protein (MAP) kinases pathway in the enoxaparin-mediated effect. The experiments were performed on the isolated resistance arteries of young (4 months old),

Background: Chronic venous insufficiency (CVI) is a common medical problem that may result in significant mor-bidity and mortality. Platelets are key players in haemostasis and thrombosis, but their role in the development of venous thrombosis is more controversial. Aim: The purpose of this study was to investigate platelet properties in CVI and their interaction with the venular endothelium. Methods: Human peripheral venules were explanted during

The aim of the present study was to examine the effects of obesity alone and obesity associated with Type 2 diabetes on the structure, vascular reactivity and response to insulin of isolated human subcutaneous fat arterioles; these effects were correlated with the expression of insulin-signalling proteins. Periumbilical subcutaneous adipose tissue was explanted during surgery, small arterioles(internal diameter 220+− 40 μm) were dissected out

Background: Chronic venous insufficiency (CVI) is a common medical problem that may result in significant mor-bidity and mortality. Platelets are key players in haemostasis and thrombosis, but their role in the development of venous thrombosis is more controversial. Aim: The purpose of this study was to investigate platelet properties in CVI and their interaction with the venular endothelium. Methods: Human peripheral venules were explanted during

The aim of this study was to determine the effect of simultaneous hypertension and hypercholesterolemia on platelet activation, nitric oxide (NO)production and oxidative stress, and to evaluate the role of irbesartan, an angiotensin II type 1 receptor antagonist. Methods: Golden Syrian hamsters were divided into three groups: controls, C (fed a standard diet); hypertensive-hypercholesterolemic, HH(fed a diet enriched in 3% cholesterol, 15% butter