Scopul nostru este sprijinirea şi promovarea cercetării ştiinţifice şi facilitarea comunicării între cercetătorii români din întreaga lume.
Sterol 14α-demethylase (cytochrome P450 family 51 (CYP51)) is an essential enzyme occurring in all biological kingdoms. In eukaryotes, it is located in the membrane of the endoplasmic reticulum. Selective inhibitors of trypanosomal CYP51s that do not affect the human CYP51 have been discovered in vitro and found to cure acute and chronic mouse Chagas disease without severe side effects in vivo. Crystal structures indicate that CYP51 may be more
Read moreSox2 and Pax6 are transcription factors that direct cell fate decision during neurogenesis, yet the mechanism behind how they cooperate on enhancer DNA elements and regulate gene expression is unclear. By systematically interrogating Sox2 and Pax6 interaction on minimal enhancer elements, we found that cooperative DNA recognition relies on combinatorial nucleotide switches and precisely spaced, but cryptic composite DNA motifs. Surprisingly, all
Read moreSix bacterial ecophysiological groups from Pleistocene sediment samples collected from two Romanian caves were identified and evaluated for their potential contribution to the interpretation of paleoclimate. Denitrifiers and nitrite oxidizers were present in the culture plates of all samples, the ammonia oxidizers were absent, and the iron-reducers were confirmed solely in the deepest sample of one of the caves. The aerobic mesophilic heterotrophs
Read moreThe Coandã effect is an interesting phenomenon in fluid mechanics discovered by the Romanian inventor Henri Marie Coandã. The physics of the Coandã effect is based on the property of a jet flow to attaches itself to a nearby surface and to remain attached even when the surface bends away from the initial jet direction. In free surroundings, a jet of fluid entrains and mixes with its surroundings as it flows away from a nozzle. The final result
Read moreCells are under constant attack from genotoxins and rely on a multifaceted DNA damage response (DDR) network to maintain genomic integrity. Central to the DDR are the ATM and ATR kinases, which respond primarily to double-strand DNA breaks (DSBs) and replication stress, respectively. Optimal ATR signaling requires the RAD9A-RAD1-HUS1 (9-1-1) complex, a toroidal clamp that is loaded at damage sites and scaffolds signaling and repair factors. Whereas
Read moreInocutis tamaricis is a lignicolous basidiomycete associated exclusively with Tamarix species. The first Romanian record of this species is reported from Constanţa city near the Black Sea coast where it was detected on Tamarix tetrandra. We noticed that in pure culture it forms swollen hyphae in the aerial mycelium, which have not been reported so far for I. tamaricis
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