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Uptake of sialic acid by human erythrocyte. Characterization of a transport system.

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Bulai T, Bratosin D, Artenie V, Montreuil J.

Editorial: Biochimie, Jan;85(1-2):., p.241-244, 2003.


Upon incubation of human red blood cells (RBC) with [4-9-14C] N-acetylneuraminic acid, the cells incorporated this sugar, as demonstrated by the identification of labelled N-acetylmannosamine in the cytosol, as a result of the action of the sialic acid pyruvate-lyase we discovered previously (Biochimie 84 (2002) 655). The mechanism is saturable and indicates the presence of a limited number of transporter molecules in the RBC membrane. This transport process may have relevance to the desialylation of membrane glycoconjugates which occurs during ageing of erythrocytes

Cuvinte cheie: sialat pyruvate-lyase;erythrocytes,red blood cells,sialic acid;transporter