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Control and variability of gene expression in profile in evaluating the ecotoxin effects

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Iacobas DA, Urban M, Iacobas S, Spray DC

Editorial: Advances in Ecological Sciences, 10, p.733-742, 2001.


the spotting microarray technique, consisting in large sets of DNA sequences spotted on poly-L-lysine coated glass microscope slides, was developed to analyze genome-wide expression patterns. It is a tool to quantitatively monitor gene expression profiles and to analyze the alterations produced by genetic diseases, or induced by treatments, abnormal nutrition and toxins. The pre-hilbert space of standard gene expression, based on the normal variability in gene profiles of each population from the ecosystem, is introduced. in this space, every point represents a possible gene profile and every continuous curve a possible genetic evolution. The gene clusters are identified by the correlation coefficients and the prominent gene of every cluster selected from the criteria of highest connective power and smallest variability. We define the “genomic patholog” as the Euclidian distance separating the representative point of the population from the unit, 0-centered hypersphere.

Cuvinte cheie: ecotoxicology, gene expression, genomic patholog