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Cell death pattern after angiotensin receptor (AT1) blockade in developing and mature rat kidney

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: V. Jinga, S. Persu, Lavinia G. Hinescu, A. Pociu, V. Voicu, M. Hinescu

Editorial: Blackwell Synergy, © 2002 BJU International 90(Suppl. 2), 201–207, 90(Suppl.2), p.201-207, 2002.


Objectives This study was designed to examine the consequences of sustained
AT1 receptor inhibition on early postnatal rat kidney development
and to compare the results with apoptotic index measured in adult rat
Materials Wistar rats pups were randomized into 14 groups (n = 10) and
daily treated with losartan (25 mg/kg body weight), for different periods
(from 3 days to 2weeks). Adult rat groups were treated with same dose,
and similar periods of time. At the end of experiment, animals were killed.
Kidneys were processed for examination by electron microscopy, or
processed after a protocol (revealing nuclear alterations) for confocal
Results Both methods confirmed a significant increase in apoptotic index
in developing kidney, after blockade of AT1 receptors. Apoptotic cells were
mainly located in the tubular structures, which were very often dilated,
mainly in the inner stripe of outer medulla. Tubular abnormalities and
high rate of apoptosis appeared soon after the treatment was initiated.
Further administration of drug did not additionally modify the kidney
architecture. When adult animals were examined in similar conditions,
no change in the apoptotic index was observed.
Conclusions Cell damage in kidney after exposure to losartan may be correlated
to mechanisms triggering excessive cell death. However, in adult
subjects, AT1 receptor blockade exerts not effects on kidney architecture.
© 2002 BJU International 90(Suppl. 2), 201–207

Cuvinte cheie: Cell death, angiotensin