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Resonance or Integration? Self-sustained Dynamics and Excitability of Neural Microcircuits

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Muresan RC, Savin C

Editorial: Journal of Neurophysiology, 97(3), p.1911-1930, 2006.


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We investigated spontaneous activity and excitability in large networks of artificial spiking neurons. We compared three different spiking neuron models, namely the integrate-and-fire (IF), regular spiking (RS) and resonator (RES). First, we show that different models have different frequency-dependent response properties, yielding large differences in excitability. Then, we investigate the responsiveness of these models to a single afferent inhibitory/excitatory spike, and calibrate the total synaptic drive such that they would exhibit similar peaks of the post-synaptic
potentials (PSP). Based on the synaptic calibration, we build large microcircuits of IF, RS and RES neurons and show that the resonance property favors homeostasis and self-sustainability of the network activity. On the other hand, integration is producing instability while it endows the network with other useful properties, such as responsiveness to external inputs. We also investigate other potential sources of stable self-sustained activity and their relation to the membrane properties of neurons. We conclude that resonance and integration at the neuron level might interact in the brain to promote stability as well as flexibility and responsiveness to external input and that membrane properties, in general, are essential for determining the
behavior of large networks of neurons.

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Cuvinte cheie: Resonance, integration, neuron, dynamics, microcircuit