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Modeling of mixing in stirred bioreactors. 2. Mixing time for non-aerated fermentation broths

Domenii publicaţii > Stiinte ingineresti + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Corneliu Oniscu, Anca-Irina Galaction, Dan Cascaval, Florina Ungureanu

Editorial: Biochemical Engineering Journal, 12, p.61-69, 2002.


The mixing time is one of the most useful criterion for mixing intensity of fermentation broths and for scale-up of biosynthesis processes. This parameter value depends mainly on the rheological properties of the broths, biomass concentration and morphology, mixing system characteristics and fermentation conditions.
For quantifying the influence of these factors on mixing efficiency for stirred bioreactors, these studies were carried out for non-aerated suspensions of bacteria (Propionibacterium shermanii), yeasts (Saccharomyces cerevisiae) and fungus (Penicillium chrysogenum, free mycelia and mycelial aggregates) of different concentrations, using a laboratory bioreactor with double turbine impeller. By means of the experimental data and using a multiregression analysis method, some mathematical correlations for mixing time were established. The proposed equations are adequate for the flow regime of Re < 25,000.

Cuvinte cheie: Biochemical Engineering, Biotechnology, Bioreactors