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Plasma markers of endothelial dysfunction in type-2 diabetes patients

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Moldoveanu E., Tanaseanu C, Tanaseanu S., Kosaka T., Manea G., Marta D.S., Popescu L.M.

Editorial: European Journal of Internal Medicine, 17(1), p.38-42, 2006.


Background: Type 2 diabetes, or non-insulin-dependent diabetes mellitus, represents an independent risk factor for cardiovascular diseases
(CVD), being characterized by a continuous low-grade inflammation and endothelial activation state. Atherosclerotic lesions occur in
diabetic patients at an earlier age with severe clinical manifestations and poor outcome. Our objective was to investigate the correlation
between lipoprotein-associated phospholipase A2 (PLA2-LDL), myeloperoxidase (MPO), and paraoxonase (PON), enzymes implicated in the
evolution of endothelial dysfunction associated with type 2 diabetes.
Methods: One hundred diabetic patients [50 without documented coronary artery disease (group 1) and 50 with CVD (group 2)] and 46
healthy controls were investigated for PLA2-LDL, MPO, and PON activities.
Results: PLA2-LDL activity was significantly higher in group 2 than in group 1 and among controls. PON activity was lower in group 1 than
in controls, reaching the lowest level in group 2. MPO activity was higher in type 2 diabetics than among controls, with similar values in
groups 1 and 2.
Conclusions: The evaluation of PLA2-LDL, MPO, and PON activities may improve early diagnosis of CVD in asymptomatic patients with
type 2 diabetes and can help to evaluate accelerated atherosclerosis and microvascular disease.

Cuvinte cheie: Inflamatie, fosfolipaza A2, Paraoxonaza, Mieloperoxidaza // Inflammation, Lipoprotein-associated phospholipase A2, Paraoxonase, Myeloperoxidase