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SPR imaging antimucin-mucin bioaffinity based biosensor as label-free tool for early cancer diagnosis. Design and detection principle

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã


Editorial: Journal of Optoelectronics and Advanced Materials, 9(6), p.1883-1889, 2007.


This paper addresses the actual increasing interest in early cancer diagnosis, by describing a novel approach in designing a
modern new and efficient label-free SPR Imaging biosensor based on the capacity of antimucin antibodies to prove cancer
occurrence by monitoring mucin overexpression. The design, functioning principle of the biosensor and the analysis
methods are presented. This new generation of sensors is intended as a revolutionary diagnosis tool exploiting the very
sensitive and label-free optical SPR Imaging technique, ideally corresponding to the study of ultrathin biomolecular layers
and biological interactions. Saliva is used as biologic fluid to be analysed, mainly due to its non-invasive and stress-free
collection. Nevertheless, the described Imaging method allows the acquisition of data for the entire probe simultaneously,
this affording the enormous advantage of analysing a big number of samples at once, in a very precise, reproducible and
brief procedure, easy to implement in any diagnosis centres.

Cuvinte cheie: Bioaffinity, Biosensor, Cancer diagnosis