This paper addresses the actual increasing interest in early cancer diagnosis, by describing a novel approach in designing a modern new and efficient label-free SPR Imaging biosensor based on the capacity of antimucin antibodies to prove cancer occurrence by monitoring mucin overexpression. The design, functioning principle of the biosensor and the analysis methods are presented. This new generation of sensors is intended as a revolutionary diagnosis

The design of a macromolecular bone graft with interconnected macroporosity represents a major challenge in the field of orthopaedic biomaterials. Such a synthetic graft would combine the biocompatibility and the biomechanical behavior with a micro-architecture allowing the osteoconduction through the colonization of the implant by bony cells and blood vessels. Macroporous pHEMA blocks were obtained by polymerizing 2-hydroxyethyl methacrylate around

Polymers are widely used in medicine for vascular prostheses, bone substitutes, and devices for controlled release. Among these polymers, poly(2-hydroxyethyl methacrylate) (pHEMA) is the most employed. To confer particular properties, pHEMA can be copolymerized with other monomers or in the presence of plasticizers or crosslinking agents. The influence of the length of crosslink chains on swelling, surface rugosity, hardness, and stiffness of crosslinked

Polymers can be interesting alternatives to bone grafts; they must present suitable mechanical and osteoconductive properties. Biomimetic properties may be a key factor for the recognition by bone cells. Methacryloyloxyethyl phosphate (MOEP) was found to enhance hydroxyapatite deposition. The copolymer containing MOEP and 1-vinyl-2-pyrrolidinone (50-50%) binds large amounts of calcium. Particles of the copolymer were used to fill large cranial bone

Methacryloyloxyethyl phosphate is a methacrylic monomer used to modify different substrates by copolymerisation, in order to enhance hydroxyapatite deposition onto their surfaces. We report the synthesis of two copolymers series using increasing concentrations of methacryloyloxyethyl phosphate with (diethylamino) ethyl methacrylate and 1-vinyl-2-pyrrolidinone. Reactivity ratios were evaluated for the two copolymer systems. The influence of phosphate