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Utility of Targeted Glucocorticoids in Cancer Therapy.

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Banciu, M., Schiffelers, R. M., Metselaar, J. M., Storm, G.

Editorial: J Liposome Res., 18(1), p.47-57, 2008.


Glucocorticoids can inhibit solid tumor growth via downregulation of tumorassociated
inflammation/angiogenesis. In this minireview we describe the possible
mechanisms of glucocorticoid action in tumor growth inhibition. We also present an
overview of the current status of tumor-targeted glucocorticoid delivery. It appears
that long-circulating liposomes are the only targeting system currently being explored
for this purpose.

Cuvinte cheie: glucocorticoids, tumor targeting, angiogenesis, inflammation