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Scanning electronic microscopy study of new pyrazinamide compounds with metallic ions

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: T.Jurca, E.Marian

Editorial: Revista Farmacia , nr.2,Vol. 57,, p.p.247-254, 2009.


In this study is presented the manner in which are prepared four pyrazinamide compounds with transitional metals ions, their physico-chemical properties, the results of the elementary analysis, as well as the examination by scanning electronic microscopy of these compounds’ particles form. The FT-infrared (4000-400 cm-1) spectra of pyrazinamide (PZA), [Cu(PZA)2]Cl2 and [Cu(PZA)2(C6H5COO)2 were recorded. The observed wavenumbers were analyzed and assigned to different normal modes of vibration of the molecule.
Pyrazinamide (PZA) is among the first-line drugs for the treatment of tuberculosis, which seems to reappear as a frequent disease.
With the assistance of the scanning electronic microscopy, the granules’ surfaces aspect may be observed, the X-rays spectres that show the presence of the elements on the analyzed micro area and the chemical composition diagram per granule for each newly synthesized compound.
The examinations were realized using the scanning electronic microscope SEM type Jeol 5600 LV, having mounted an X-rays spectrometer type Oxford Instrument.(1)
Details concerning the spatial architecture and the crystalline structure will be obtained by vibration spectroscopy of magnetic resonance and X-rays diffraction.(2)

Cuvinte cheie: pirazinamida, microsopie electronicã de baleiaj, structura cristalinã, FT-IR // pyrazinamide, scanning electronic microscopy, crystalline structure, FT-IR