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FANCD2 hurdles the DNA interstrand crosslink (review)

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Moldovan GL, D’Andrea AD

Editorial: Cell, 139, p.1222-1224, 2009.


Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process.

Cuvinte cheie: DNA repair, Fanconi Anemia, DNA replication, cell cycle regulation, cancer