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Endothelial transcytosis in health and disease

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Maya Simionescu, Doina Popov, Anca Sima

Editorial: Springer Verlag Berlin / Heidelberg, Cell Tissue Res , 335, p.27-40, 2009.


The visionaries predicted the existence of transcytosis in endothelial cells; the cell biologists deciphered its
mechanisms and (in part) the molecules involved in the process; the cell pathologists unravelled the presence of
defective transcytosis in some diseases. The optimistic perspective is that transcytosis, in general, and receptor-mediated transcytosis, in particular, will be greatly exploited in order to target drugs and genes to exclusive sites in and on endothelial cells (EC) or underlying cells. The current recognition that plasmalemmal vesicles (caveolae) are the vehicles involved in EC transcytosis has moved through various phases from intial considerations of caveolae as unmovable sessile non-functional plasmalemma invaginations to the present identification of a multitude of molecules and a crowd of functions
associated with these ubiquitous structures of endothelial and epithelial cells. Further understanding of the molecular machinery that precisely guides caveolae through the cells so as to reach the target membrane (fission, docking, and
fusion), to avoid lysosomes, or on the contrary, to reach the lysosomes, and discharge the cargo molecules will assist in the design of pathways that, by manipulating the physiological
route of caveolae, will carry molecules of choice (drugs, genes) at controlled concentrations to precise destinations.

Cuvinte cheie: Endoteliu, caveolae, proteine plasmatice, patologie // Transcytosis . Endothelium, Caveolae, Plasma proteins, Disease