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Arterial smooth muscle cells dysfunction in hyperglycaemia and hyperglycaemia associated with hyperlipidaemia: from causes to effects

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Doina Popov, Elena Constantinescu

Editorial: J. Eckel, Informa, U.K. Ltd, Archives of Physiology and Biochemistry, 114(2), p.150-160, 2008.


Given the important role of smooth muscle cells in arterial wall dysfunction in diabetes, as well as in diabetes associated with accelerated atherosclerosis, we provide a brief review of the recent achievements in identification of signalling molecules
underlying their altered cellular responses, and examine the consequences of these pathological insults on smooth muscle cells properties. The original results emerging from the Golden Syrian hamster model (rendered diabetic or simultaneously hyperlipidaemic-diabetic) and from human aortic smooth muscle cells cultured in 25 mM glucose (to mimic diabetic condition) or sera of obese type 2 diabetic patients (to mimic the metabolic syndrome condition) are presented in this context. We conclude this review with several open issues disclosed by the most recent literature that deserve essential
attention for targeting the translational medicine.

Cuvinte cheie: Celule musculare netede umane, modularea fenotipului, crestere, proliferare, molecule de semnalizare // Human aortic smooth muscle cells, phenotypic modulation, growth, proliferation, signalling molecules.

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