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Low basal levels of circulating adiponectin in patients undergoing coronary stenting predict in-stent restenosis, independently of basal levels of inflammatory markers: lipoprotein associated phospholipase A2, and myeloperoxidase

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Moldoveanu E, Mut-Vitcu B, Tanaseanu GR, Marta DS, Manea G, Kosaka T, Vidulescu C, Tanaseanu C

Editorial: Clinical Biochemistry doi:10.1016/j.clinbiochem.2008.09.109 , 41(18), p.1429-1433, 2008.


Objective: The aim of this study was to find a pre-interventional marker with the capacity to predict in-stent restenosis (ISR). Considering the
anti-atherosclerotic role of adiponectin (APO), an adipocytokine with anti-inflammatory, anti-proliferative, anti-oxidative and anti-thrombotic
properties, low plasma levels of APO might be correlated with the risk of ISR. We investigated the correlations between the plasma levels of APO
and two markers of inflammation: lipoprotein associated phospholipase A2 (Lp-PLA2) and myeloperoxidase (MPO).
Design and methods: 80 patients with angiographically significant stenosis underwent percutaneous coronary intervention (PCI) with bare
metal stent. Plasma APO concentration and plasma Lp-PLA2 and MPO activities were evaluated immediately before and after PCI, then followedup
at 24, 48, 72 h, and at 1, 3, 6 months, respectively. ISR was evaluated at 6 months after stenting by follow-up coronary angiograms, and it was
defined as N50% stenosis of the target lesion.
Results: ISR was present in 33.75% of patients. Baseline APO plasma concentration, measured before PCI, was lower in ISR patients than those
without ISR [3.97 (±1.05) vs 6.65 (±2.95) μg/mL respectively, pb0.001]. The patients with APO values less than 4.9 μg/mL at discharge were more
susceptible to develop ISR (odd ratio, 4.27; 95% CI, 1.56–11.72, pb0.001). ISR rate was independent of inflammation markers Lp-PLA2 and MPO
baseline values, measured before PCI.
Conclusions: The persistence of a low APO plasma level at discharge and 6 months afterwards may be used as a clinically useful marker for
ISR prediction in patients undergoing PCI.

Cuvinte cheie: In-stent restenosis; Adiponectin; Lipoprotein associated phospholipase A2; Myeloperoxidase

URL: doi:10.1016/j.clinbiochem.2008.09.109