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Synthesis of new conformationally constrained pentasaccharides as molecular probes to investigate the biological activity of heparin

Domenii publicaţii > Chimie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: E. Sisu, S.Tripathy, J.M. Mallet, P.A. Driguez, J.P. Hérault, P. Sizun, J.M. Herbert, Maurice Petitou, P. Sinay

Editorial: Elsevier, Biochimie, 1-2, p.91-99, 2003.


We have synthesized three new antithrombin activating pentasaccharides displaying various sulfation patterns on the reducing end unit (H).
We found that when L-iduronic acid stands in the 2S0 conformation, the sulfate groups at positions 3 and 6 of the reducing end unit are
practically devoid of influence on the activation of antithrombin. This suggests that the positive role of these sulfates is more related to their
ability to shift the conformational equilibrium of L-iduronic acid towards 3S0 than to directly interact with the protein.

Cuvinte cheie: Heparina,Conformatie, Antitrombina, Factor Xa; Sulfat // Heparin; Conformation; Antithrombin; Factor Xa; Sulfate