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The human trigeminal ganglion: c-kit positive neurons and interstitial cells.

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Rusu MC, Pop F, Hostiuc S, Dermengiu D, Lala AI, Ion DA, Manoiu VS, Mirancea N.

Editorial: Elsevier, Ann.Anat., 193(5), p.403-411, 2011.

Rezumat:

OBJECTIVES: The presence of c-kit positive neurons in sensory ganglia has been
verified in various species but not in humans. Our aim has been to identify
whether human primary trigeminal neurons label with c-kit/CD117 and thus, whether
data gathered in animal studies can be extrapolated to humans. We also intended
to establish whether, and which non-neuronal cells also label with c-kit in the
trigeminal ganglion. METHODS: Human adult trigeminal ganglia from eight cadavers
were processed for immunohistochemistry on paraffin embedded samples using
monoclonal antibodies for CD117/c-kit, and three additional trigeminal ganglia
were used for transmission electron microscopy (TEM). To evaluate which neuronal
type (A or B) was labeled with c-kit, we evaluated the same neurons on adjacent
sections labeled with antibodies for neurofilaments (NF). RESULTS: c-kit has
labeled trigeminal neurons (TNs), mast cells and interstitial cells (ICs) within
the trigeminal ganglion. c-kit+TNs were NF-and thus were strongly presumed to be
nociceptive, as such neurons are known to be NF-poor. c-kit+ICs with long and
moniliform processes intermingled with the satellite glial cells (SGCs) of the
neuronal envelopes. TEM evaluations confirmed this mixed composition of the
neuronal envelopes and demonstrated that the perineuronal ICs are in fact
interstitial Cajal-like cells (ICLCs) and/or telocytes. CONCLUSIONS: c-kit+TNs
were objectified in humans and strongly presumed to be nociceptive. TNs envelopes
mostly consist of SGCs, but are also combined with ICLCs/telocytes.

Cuvinte cheie: interstitial Cajal-like cells; telocytes; CD117; nociceptive neurons; spinal ganglion; neurofilaments; TEM.