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Intraplatelet oxidative/nitrative stress: inductors, consequences, and control

Domenii publicaţii > Biologie + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: N. Alexandru, D. Popov, A. Georgescu

Editorial: Trends Cardiovasc Med, 20, p.232-238, 2010.


This article provides an overview of the current knowledge on intraplatelet
oxidative/nitrative stress, an abnormality associated with platelet
activation and hyper-reactivity. The first issue discussed is related to
induction of platelet endogenous stress by the molecules present within
the circulating (extracellular) milieu that bathes these cells. The second
issue concerns the intraplatelet oxidative/nitrative stress associated
with specific pathologies or clinical procedures and action of particular
molecules and platelet agonists as well as of the specialized intraplatelet
milieu and its redox system; the biomarkers of endogenous oxidative/
nitrative stress are also briefly outlined. Next, the association between
intraplatelet oxidative/nitrative stress and the risk factors of the metabolic
syndrome is presented. Then, the most recent strategies aimed at
the control/regulation of platelet endogenous oxidative/nitrative stress,
such as exploitation of circulating extracellular reactive oxygen species
scavengers, manipulation of platelet molecules, and the use of antioxidants,
are discussed. Finally, the results of studies on platelet-dependent
redox mechanisms, which deserve immediate attention for potential
clinical exploitation, are illustrated.

Cuvinte cheie: intraplatelet oxidative/nitrative stress, biomarkers, metabolic syndrome, platelet-dependent redox mechanisms, strategies