Scopul nostru este sprijinirea şi promovarea cercetării ştiinţifice şi facilitarea comunicării între cercetătorii români din întreaga lume.
Autori: Rusu MC, Nicolescu MI, Jianu AM, Lighezan R, Mănoiu VS, Păduraru D.
Editorial: Cell Biol Int, 2012.
Telocytes (TCs) are actually defined as being stromal cells with specific long
and thin prolongations, called telopodes (Tp). They were positively identified in
various tissues up to now. We report here for the first time the presence of TCs
in the structure of esophagus. Such cells were identified under transmission
electron microscopy (TEM) in esophageal samples of Wistar rats (N=5) and were
found beneath the basal epithelial layer, in submucosa, closely related to smooth
as well as striated muscular fibers, and also in adventitia. They were closely
related to mast cells, macrophages, and microvessels. Hybrid morphologies of
stromal cells processes were found: cytoplasmic processes continued distally in a
telopodial fashion. Telopodes alone may not be enough for a safe diagnostic of
TCs in TEM; a larger set of specific standards (such as the telopodial emergence,
and the sizes of the cell body and telopodes) should be considered to
differentiate TCs to various species of fibroblasts. The morphological and
ultrastructural specific features should make the difference between TCs and
interstitial cells of Cajal in the digestive tract.
Cuvinte cheie: connective tissue, esophagus, fibroblast, interstitial Cajal cell, interstitial Cajal-like cell, telopode