Inscriere cercetatori

Premii Ad Astra

premii Ad Astra

Asociația Ad Astra anunță lansarea proiectului Premiilor Ad Astra 2022 (link aici), care își propune identificarea și popularizarea modelelor de succes, a rezultatelor excepționale ale cercetătorilor români din țară și din afara ei. Regulamentul de participare se poate gasi aici, iar  pagina de inscriere se poate accesa aici.

Asociatia Ad Astra a cercetatorilor romani lanseaza BAZA DE DATE A CERCETATORILOR ROMANI DIN DIASPORA. Scopul acestei baze de date este aceea de a stimula colaborarea dintre cercetatorii romani de peste hotare dar si cu cercetatorii din Romania. Cercetatorii care doresc sa fie nominalizati in aceasta baza de date sunt rugati sa trimita un email la cristian.presura@gmail.com

Early onset of podocytes apoptosis – a TEM study in streptozotocin-induced diabetic rats

Domenii publicaţii > Ştiinţe medicale + Tipuri publicaţii > Articol în revistã ştiinţificã

Autori: Bălăşescu E, Rusu MC, Vrapciu AD, Mirancea N, Mănoiu VS, Stan CI

Editorial: Rom J Morphol Embryol, 55(1), p.71-5, 2014.

Rezumat:

Cell death types are usually defined by morphological criteria. Even though podocyte loss is associated with various cell death mechanisms, podocyte apoptosis is rarely detected. The purpose of this study is to evaluate whether morphological signs of apoptotic cell death could be detected in early streptozotocin-induced diabetes in rats kidneys. There were used five Wistar rats, and renal tissue samples were drawn after three weeks of disease and further evaluated in transmission electron microscopy (TEM). Podocytes damage was indicated by two major findings: foot processes effacement, viewed as loss of cell processes, and chromatin condensation and margination (partial karyopyknosis: peculiar nuclear morphologies – partly normal, euchromatic, and partly positive for karyopyknosis and nuclear shrinkage). Mitotic glomerular endotheliocytes were also encountered. Podocytes cell death commitment and detachment appeared as concomitant events. However, karyopyknosis is not a specific feature of apoptosis. Thus, further biochemical evaluations are needed to distinguish between different pathways of podocytes death.

Cuvinte cheie: kidney, diabetic nephropathy, foot processes, renal glomerulus, podocytes detachment, TEM

URL: http://www.rjme.ro/RJME/resources/files/550114071075.pdf