The reproduction of hormonal effects by macromolecular RNA
Investigations on the possibility to reproduce the effects of estradiol-17beta in an endocrino-dependent organ - the vagina - by local macromolecularRNA have been carried out. Macromolecular RNA was extracted from ovariectomized female rat vaginas. After intravaginal application of extracted RNA in ovariectomized animals the appearance of hormonal effects expressed by epithelial hyperplasia, hasty keratinization and evident exfoliation has been ascertained.
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