Pyrazinamide (pyrazine carboxamide PZA), is a nicotinamide analogue, that has been used for almost 50 years as a first-line drug to treat tuberculosis. The parent molecule PZA and some of its complexes are widely used, due to their antimicrobial properties. The FT-infrared (4000-400 cm-1) and EPR spectra of pyrazinamide (PZA) and [Cu(PZA)2](C6H5COO)2 were recorded. We have investigated by SEM the resulted complex combination. Tipical SEM pictures

In this study is presented the manner in which are prepared four pyrazinamide compounds with transitional metals ions, their physico-chemical properties, the results of the elementary analysis, as well as the examination by scanning electronic microscopy of these compounds’ particles form. The FT-infrared (4000-400 cm-1) spectra of pyrazinamide (PZA), [Cu(PZA)2]Cl2 and [Cu(PZA)2(C6H5COO)2 were recorded. The observed wavenumbers were analyzed and

Nicotinic acid and their complexes combination with copper and cobalt acetate were characterized using Raman and SERS spectroscopy. FT-Raman spectra emphasize significant differences in the wavenumber and intensity of aromatic system bands and in the ranges of the ring modes upon coordination. SERS results revealed chemisorptions of the ligand species through the hydroxyl groups with respect to the metal surface. The differences between the chemisorbed

Pyrazinamide (PZA) is among the first-line drugs for the treatment of tuberculosis, which seems to reappear as a frequent disease. In this study is investigate the thermal behaviour of new transition metal complexes of PZA and is searched for a correlation between structure and thermal transformations, described as multi-step processes consisting in crystaline phase transition, decomposition, melting and thermo-oxidation.