Metformin is the most used oral antidiabetic agent, especially for type 2 diabetes. It is a biguanide glucose-lowering agent, highly recommended for obese patients. Purpose. Analytical determination of metformin for bioequivalence studies. Materials and method. Reversed-phase mechanism with ultraviolet (UV) detection and deproteinization plasma samples were chosen for the determination of metformin. Results. Plasma samples were deproteinisated (1:1.5v/v);

Tramadol hydrochloride is a centrally acting opioid analgesic agent marketed for the treatment of moderate to severe pain. Objectives. The objectives were development and validation of a extraction method for the simultaneous HPLC determination of Tramadol and its active metabolite O-desmethyltramadol (M1) in plasma in order to use in bioequivalence studies. Material and method. A reversed-phase mechanism with fluorescence detection and liquid/liquid

This paper presents the layout and the technological steps for an interdigitally integrated capacitor used for gas detection. Silicon micromachining technology is applied for manufacturing the sensor substrate. The sensitive layer used is phthalocyanine (Pc) deposed by EDL (evaporated dyes layers technique). Many solutions were found using the phthalocyanine derivatives deposition technique. Considering the different sensitivities of phthalocyanines

Tramadol is an effective and well tolerated agent to reduce pain resulting from trauma, renal or biliary colic and labor, and also for the management of chronic pain of malignant or nonmalignant origin, particularly neuropathic pain. It appears to produce less dependence than equianalgesic doses of strong opioids. Tramadol, a centrally acting analgesic structurally related to codeine and morphine, consists of two enantiomers, both of which contribute