Post Doctoral Positions-Vascular Biology Research We are seeking qualified individuals at the post doctoral level (Ph.D., M.D.) to conduct research in vascular and circadian biology at the Medical College of Georgia, in Augusta, Georgia, U.S.A. Students with interest attaining research experience are also invited. Both domestic and international applicants are encouraged to apply. The Medical College of Georgia is located in the beautiful city of

My laboratory is seeking qualified individuals at the post doctoral level (Ph.D., M.D.) to conduct research in cardiovascular biology at the Medical College of Georgia, in Augusta, Georgia, U.S.A. Students with interest attaining research experience are also invited. Both domestic and international applicants are encouraged to apply. The Medical College of Georgia is located in the beautiful city of Augusta. World renown as host of the golf tournament

My laboratory is seeking qualified individuals at the post doctoral level (Ph.D., M.D.) to conduct research in cardiovascular biology at the Medical College of Georgia, in Augusta, Georgia, U.S.A. Students with interest attaining research experience are also invited. Both domestic and international applicants are encouraged to apply. The Medical College of Georgia is located in the beautiful city of Augusta. World renown as host of the golf tournament

Angiogenesis is a complex process involving endothelial cell (EC) proliferation, migration, differentiation, and organization into patent capillary networks. Nitric oxide (NO), an EC mediator, has been reported to be antigenic as well as proangiogenic in different models of in vivo angiogenesis. Our aim was to investigate the role of NO in capillary organization using rat microvascular ECs (RFCs) grown in three-dimensional (3D) collagen gels. RFCs

The vascular endothelium mediates the ability of blood vessels to alter their architecture in response to hemodynamic changes; however, the specific endothelial-derived factors that are responsible for vascular remodeling are poorly understood. Here we show that endothelial-derived nitric oxide (NO) is a major endothelial-derived mediator controlling vascular remodeling. In response to external carotid artery ligation, mice with targeted disruption

Nitric oxide plays an important role in cardiovascular homeostasis. In this review, the regulation of the three nitric oxide synthase isoforms in the cardiovascular system are examined at molecular and cellular levels. In addition, recent information gleaned from the use of NOS knockout mice are discussed.

To define the cellular events of vascular remodeling in mice, we measured blood flow and analyzed the morphology of remodeled vessels at defined points after a flow-reducing remodeling stimulus for 3, 7, 14, and 35 days. Acute ligation of the left external carotid artery reduced blood flow in the left common carotid artery (LC) compared with sham and contralateral right common carotid arteries (RCs). In morphometric analyses, the decrease in diameter

The serine/threonine protein kinase Akt (protein kinase B) phosphorylates endothelial cell nitric oxide synthase (eNOS) and enhances its ability to generate nitric oxide (NO). Because NO is an important regulator of vasomotor tone, we investigated whether Akt can regulate endothelium-dependent vasomotion in vivo using a rabbit femoral artery model of gene transfer. The endothelium of isolated femoral arteries was infected with replication-defective

Caveolin-1, the primary coat protein of caveolae, has been implicated as a regulator of signal transduction through binding of its "scaffolding domain" to key signaling molecules. However, the physiological importance of caveolin-1 in regulating signaling has been difficult to distinguish from its traditional functions in caveolae assembly, transcytosis, and cholesterol transport. To directly address the importance of the caveolin scaffolding domain