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Publicatii proprii
A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT.
The C-terminus of the voltage-gated calcium channel Cav1.2 encodes a transcription factor, the calcium channel associated transcriptional regulator (CCAT), that regulates neurite extension and inhibits Cav1.2 expression. The mechanisms by which CCAT is generated in neurons and myocytes are poorly understood. Here we show that CCAT is produced by activation of a cryptic promoter in exon 46 of CACNA1C, the gene that encodes CaV1.2. Expression of CCAT
Read moreMotor abnormalities as a putative endophenotype for Autism Spectrum Disorders.
Autism Spectrum Disorders (ASDs) represent a complex group of behaviorally defined conditions with core deficits in social communication and the presence of repetitive and restrictive behaviors. To date, neuropathological studies have failed to identify pathognomonic cellular features for ASDs and there remains a fundamental disconnection between the complex clinical aspects of ASDs and the underlying neurobiology. Although not listed among the core
Read moreEosinophilic esophagitis
Eosinophilic esophagitis is a chronic, immune-mediated disorder, isolated to the esophagus. Current theory suggests that the former may be caused by cell-mediated food hypersensitivity or may be a subset of eosinophilic gastrointestinal disease, an autoimmune disorder. During the last decade, the increasing prevalence of EoE has been recognized in pediatric populations. Reports support the efficacy of dietary restriction or corticosteroid therapy.
Read moreRecording of self-induced waveguides in lithium niobate at 405 nm wavelength by photorefractive – pyroelectric effect
We characterize the process of soliton waveguides (SWGs) recording at 405 nm wavelength using pyroelectric effect in lithium niobate (LN) crystals. We experimentally study and discuss the influence of the input irradiance, the polarization of the signal beam, and the crystal temperature change on the waveguide writing time and mode-profile. These characteristics significantly change when changing the recording wavelength. The advantages of recording
Read moreFast writing of soliton waveguides in lithium niobate using low-intensity blue light
We experimentally demonstrate the writing of soliton waveguides in lithium niobate with blue violet light, at λ = 405 nm. This wavelength, obtained from a low-cost laser diode, allows very fast writing of soliton waveguides when comparing with the writing process using green light (532 nm). For the same writing time, there is a decrease of ~4 orders of magnitude of the light intensity necessary for writing soliton waveguides in blue. The writing
Read moreInterferometric measurement of the pyroelectric coefficient in lithium niobate
We report the measurement of pyroelectric field in LiNbO3 by introducing a new method, based on optical interferometry. The pyroelectric coefficient of the congruent LiNbO3 crystals has been determined by this method and the value obtained for it, similar to 95 mu C/(m(2).K), is consistent with previous results reported in literature, obtained by other methods.
Read moreThe role of Arabidopsis thaliana NAR1, a cytosolic iron-sulfur cluster assembly component, in gametophytic gene expression and oxidative stress responses in vegetative tissue
Iron-sulfur proteins have iron-sulfur clusters as a prosthetic group and are responsible for various cellular processes, including general transcriptional regulation, photosynthesis and respiration. The cytosolic iron-sulfur assembly (CIA) pathway of yeast has been shown to be responsible for regulation of iron-sulfur cluster assembly in both the cytosol and the nucleus. However, little is known about the roles of this pathway in multicellular organisms.
Read moreDouble Amino Functionalized Ag Nanoparticles as SERS Tags in Raman Diagnostic
Surface enhanced Raman scattering (SERS) effect is currently exploited as the basis of a new type of optical labels for in vivo investigation of the tissues, especially for early medical diagnostic. Silver colloidal nanoparticles decorated with chemisorbed cresyl violet molecular species could act as hybrid SERS labels. Their Raman scattering properties have been characterized here using different SERS techniques, and probing different excitation
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