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Asociația Ad Astra a anunțat câștigătorii Premiilor Ad Astra 2022: http://premii.ad-astra.ro/. Proiectul și-a propus identificarea și popularizarea modelelor de succes, a rezultatelor excepționale ale cercetătorilor români din țară și din afara ei.
Publicatii proprii
Calcium signaling mediates the response to cadmium toxicity in Saccharomyces cerevisiae cells
The involvement of Ca2+ in the response to high Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, and Hg2+ was investigated in Saccharomyces cerevisiae. The yeast cells responded through a sharp increase in cytosolic Ca2+ when exposed to Cd2+, and to a lesser extent to Cu2+, but not to Mn2+, Co2+, Ni2+, Zn2+, or Hg2+. The response to high Cd2+ depended mainly on external Ca2+ (transported through the Cch1p/Mid1p channel) but also on vacuolar Ca2+ (released into
Read moreThe vascular stem cell niches and their significance in the brain
AIM: This cytohistopathological study was performed for a better knowledge of phenotypes derived from pluripotent stem cells, as well as for precise location of stem cells within the vascular niche in the brain. METHODS: We used light and transmission electron microscopy to demonstrate the presence of stem cells in the vascular wall of microvessels in the cerebral and cerebellar cortex, pia mater (considered by us a cordocytic-vascular tissue), adventitia
Read moreCeliac disease microbiota and its applications
Intestinal microbiota plays an important role in maintaining the overall health of an individual. It can be affected by diet but also inflammation of the intestine due to various causes. In the last decade, particular attention has been paid to the study of the interaction between mucosal cells and intestinal microbiota, and to the host immune response to change in community structure. Here, we review the most significant studies on human microbiota
Read moreGlobotalicypridea mirabilis sp. nov. – the first non-marine ostracod taxon from the Upper Cretaceous of the Hateg Basin, Romania
A monospecific assemblage of Globotalicypridea mirabilis sp. nov. is reported from the Maastrichtian of the Hateg Basin, Romania. This new species is the first ostracod taxa described from the famous dinosaur-bearing continental deposits of the Hateg Basin. G. mirabilis sp. nov. is characterized by large, finely punctate, and posteriorly strongly inflated carapace with a few papillae on the anterior margin. This new species was restricted exclusively
Read moreSpatiotemporal variability of meteorological drought in Romania using the standardized precipitation index (SPI)
This study addresses the spatial and temporal variability of meteorological drought in Romania based on a standardized precipitation index (SPI) analysis over the period 1961-2010. The 1- and 3 mo SPI values from 124 meteorological stations were used to examine the duration, magnitude, intensity, and frequency of the drought spells. Empirical orthogonal function analysis supported the investigations on the variability of the SPI values both in time
Read moreCirculating Endothelial Progenitor Cell and platelet microparticle impact on platelet activation in hypertension associated with hypercholesterolemia
Aim: The purpose of this project was to evaluate the influence of circulating endothelial progenitor cells (EPCs) and platelet microparticles (PMPs) on blood platelet function in experimental hypertension associated with hypercholesterolemia. Methods: Golden Syrian hamsters were divided in six groups: (i) control, C; (ii) hypertensive-hypercholesterolemic, HH; (iii)‘prevention’, HHin-EPCs, HH animals fed a HH diet and treated with EPCs; (iv)
Read moreIs lung a target of diabetic injury? The novel Pros and Cons evidences
The rationale for questioning whether lung is/ or is not affected by diabetes is based on two reasons: the frequent dysfunction of the lung encountered at the newborn children of diabetic mothers and the need to understand the pathophysiology of this organ for anti-diabetics administration by inhalation. This review attempts to give an answer to the above dilemma, based on the most recent results. With this aim, Medline and PubMed data bases have
Read moreAn outlook on vascular hydrogen sulphide effects, signalling, and therapeutic potential
Hydrogen sulphide (H2S) is the most recently discovered gasotransmitter. It is endogenously generated in mammalian vascular cells and attracts substantial interest by its function as physiological relevant signalling mediator, and by its dysfunction in metabolic diseases like obesity, type 2 diabetes and their associated complications. The purpose of this review is to highlight the novel findings on vascular H2S homeostasis, pathology-associated
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