The porphyrins seem to be the most effective photosensitizers in photodynamic therapy of cancer. Monomers and dimers of sulfonated and nonsulfonated porphyrins [5,10,15,20-tetra-phenyl-porphyrin, 5,10,15,20-tetra-naphtyl-porphyrin (TNP), 5,10,15,20-tetra-p-sulfonato-phenyl-porphyrin (TS4PP) and 5,10,15,20-tetra-p-sulfonato-naphtyl-porphyrin], are studied in this paper by means of different spectral methods (UV-vis, fluorescence and polarization fluorescence).

The time-resolved photothermal methods are used in order to establish the yield of intersystem (singlet-triplet) crossing of dyes that are candidates for the application in photodynamic therapy. It is known that molecules with long living triplet state cause efficient photosensitization by direct interaction with the cells or by singlet oxygen generation. The steady state photoacoustic spectra enables one to establish the dye incorporation into cells.

The aim of the study was to investigate the influence of discrete structural differences in synthetic porphyrins on the antineoplastic effect induced in lymphoblastic cell line K562 after experimental photodynamic therapy procedure (PDT). For this study, it was synthesized 5,10,15,20-tetra-1-naphthyl-porphyrin (TNP), 5,10,15,20-tetra-p-sulphonatophenyl-porphyrin (TSPP) and their Zn complexes (ZnTSPP or ZnTNP). For all these compounds, it was optimized

The aim of the study was to correlate the uridine uptake via the alternative pathway of nucleotide biosynthesis and apoptosis associated to in vitro photodynamic (PDT) cellular treatment. We have investigated the effects exerted by porphyrins, namely 5,10,15,20-tetra-1-naphthyl-porphyrin (TNP) and 5,10,15,20-tetra-p-sulphonate-phenyl-porphyrin (TSPP). Various neoplastic and normal cells were studied: the lymphoblastic cell line K562, the histiocytic

Photodynamic therapy is an emerging method for local destruction of tumoral tissue by generating toxic oxygen species using light absorbed by an administered photosensitiser. Following administration of a photosensitiser occurs an accumulation or retention in areas of cancer and disease relative to adjacent normal tissue. The photosensitiser is inactive until irradiated by light, following which cellular destruction occurs. This explanation is a

Photodynamic therapy is a local treatment modality of cancer, based on the administration of photosensitizer, which is selectively retained al tumoral level, and which after the optical radiations exposure lead to the tumoral tissue destruction. The application of the photodynamic therapy in clinical practice presents many problems. The present study aims to correlate the refraction indices of the tumoural tissue with refractive indices of photosensitizer

In this study we evaluate in vitro the cytotoxic activity of two newly synthesized phthalocyanines (metallo-complexes) with absorption bands in the red part of the spectrum: zinc-tri-sulphonated phthalocyanine (ZnS4Pc). Two permanent animal tumor cell lines are used in the experiments: LSR-SF(SR)-transplantable sarcoma in rat induced by Rous sarcoma virus strain Schmidt-Ruppin and LSCC-SF(Mc29)-transplantable chicken hepatoma induced by the myelocytomatosis

Nanocomposite of polypyrrole and iron oxide were prepared using simultaneous gelation and polymerization processes. Varied amounts of pyrrole were added to a solution containing an Fe(III) salt as precursor and 2-metoxy ethanol as solvent. The particles were found to be nanocrystalline. However, the composites exhibited mixed phase, belonging to both the corrundum α-Fe2O3 (nonmagnetic) and the cubic phase, Fe3O4, which is ferromagnetic. The presence

Porphyrins can form a variety of structures from linear head-to-tail or J-aggregates to fractal aggregates with different and specific photophysical properties. The aggregation process of some sensitizers such as tetrakis(4-sulphonatophenyl) porphyrin (TSPP) and chlorophyll (ChL) are investigated by different spectral techniques: absorption, fluorescence, transmission and scanning microscopy. The excited states lifetimes and the aggregation process